universal buffer

DNA/RNA Defend Pro™

DNA/RNA Defend Pro™ (DRDP): Save time with extraction-free PCR!
  • inactivation of pathogens
  • stabilizes DNA
  • stabilizes RNA
  • stabilizes antigen
  • direct PCR compatible
  • lysis buffer
  • mucolytic
DNA/RNA Defend Pro™ is a nonionic detergent-based acidic medium for pathogen inactivation, stabilization of RNA/DNA/antigens, and lysis of biological samples. Compatible with extraction-free analytical procedures.

Nucleic acid stability in saliva and nasal swab stored in DRDP for 2 weeks at room temperature

RT-qPCR analysis of human RNA (CALR), human DNA (GAPDH), and viral RNA (SARS-CoV-2 E-gene) in saliva and nasal swab stored in DNA/RNA Defend Pro at room temperature for 15 days.

No extraction required - direct PCR compatible

Volume DNA/RNA Defend Pro in final RT-qPCR reaction

Direct RT-qPCR results of DNA/RNA Defend Pro compared to water control in four targets

flow cell
buffer

DNA/RNA Defend Pro™ (DRDP) is a cost-effective alternative to ESwab® and also works for RNA targets
negative
control
DNA/RNA Defend Pro™ (DRDP) is a cost-effective alternative to ESwab® and also works for RNA targets
100k
SARS-CoV-2 particles

DNA/RNA
Defend Pro*

DNA/RNA Defend Pro™ (DRDP) is a cost-effective alternative to ESwab® and also works for RNA targets
negative
control
DNA/RNA Defend Pro™ (DRDP) is a cost-effective alternative to ESwab® and also works for RNA targets
100k
SARS-CoV-2 particles

Quick antigen test compatible

* upon pH neutralization with NaOH prior to sample loading
Dr. Ivan Brukner

“As a molecular diagnostics professional, I am always looking for solutions that enhance efficiency, sensitivity, and biosafety in our workflows. The sample collection buffer DNA/RNA Defend Pro (DRDP) from InActiv Blue has been a game-changer for us. Enabling direct PCR without nucleic acid extraction has streamlined our processes, significantly reducing turnaround time and costs.

One of the biggest challenges in qPCR-based testing is overcoming PCR inhibition while maintaining high sensitivity—and DRDP has delivered on both fronts. Our validation studies confirm that even at higher sample input volumes, DRDP maintains exceptional sensitivity, making it a reliable and robust solution for molecular diagnostics.

Beyond performance, the biosafety advantages of DRDP cannot be overstated. As it inactivates viruses, it removes the risk of laboratory-associated infections, ensuring a safer work environment. It also enables decentralized testing in non-laboratory settings such as airports, schools, and walk-in clinics.

For any lab seeking to simplify workflows without compromising on accuracy and reproducibility, I highly recommend DRDP. It’s a significant step forward in molecular diagnostic testing.”

Dr. Ivan Brukner

co-director of the Molecular Microbiology Unit at Jewish General Hospital, Montréal, Canada

Do you have questions?

In the link below you’ll find answers to the most common questions regarding our products.
If you still can’t find the answer just contact us!